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Title:

In situ metabolomics of aldosterone-producing adenomas.

Document type:
Journal Article
Author(s):
Murakami, Masanori; Rhayem, Yara; Kunzke, Thomas; Sun, Na; Feuchtinger, Annette; Ludwig, Philippe; Strom, Tim Matthias; Gomez-Sanchez, Celso; Knösel, Thomas; Kirchner, Thomas; Williams, Tracy Ann; Reincke, Martin; Walch, Axel Karl; Beuschlein, Felix
Abstract:
Recent genetic examinations and multisteroid profiles have provided the basis for subclassification of aldosterone-producing adenomas (APAs). The objective of the current study was to produce a comprehensive, high-resolution mass spectrometry imaging (MSI) map of APAs in relation to morphometry, immunohistochemical profiles, mutational status, and clinical outcome. The study cohort comprised 136 patients with unilateral primary aldosteronism. Matrix-assisted laser desorption/ionization-Fourier t...     »
Journal title abbreviation:
JCI Insight
Year:
2019
Journal volume:
4
Journal issue:
17
Fulltext / DOI:
doi:10.1172/jci.insight.130356
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31484828
Print-ISSN:
2379-3708
TUM Institution:
Institut für Humangenetik
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