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Title:

Reduced blood oxygenation level dependent connectivity is related to hypoperfusion in Alzheimer's disease.

Document type:
Journal Article
Author(s):
Göttler, Jens; Preibisch, Christine; Riederer, Isabelle; Pasquini, Lorenzo; Alexopoulos, Panagiotis; Bohn, Karl Peter; Yakushev, Igor; Beller, Ebba; Kaczmarz, Stephan; Zimmer, Claus; Grimmer, Timo; Drzezga, Alexander; Sorg, Christian
Abstract:
Functional connectivity of blood oxygenation level dependent signal fluctuations (BOLD-FC) is decreased in Alzheimer's disease (AD), and suggested to reflect reduced coherence in neural population activity; however, as both neuronal and vascular-hemodynamic processes underlie BOLD signals, impaired perfusion might also contribute to reduced BOLD-FC; 42 AD patients and 27 controls underwent simultaneous PET/MR imaging. Resting-state functional MRI assessed BOLD co-activity to quantify BOLD-FC,...     »
Journal title abbreviation:
J Cereb Blood Flow Metab
Year:
2019
Journal volume:
39
Journal issue:
7
Pages contribution:
1314-1325
Language:
eng
Fulltext / DOI:
doi:10.1177/0271678X18759182
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29431005
Print-ISSN:
0271-678X
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer); Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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