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Titel:

Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis.

Dokumenttyp:
Journal Article
Autor(en):
Graetz, Christiane; Gröger, Adriane; Luessi, Felix; Salmen, Anke; Zöller, Daniela; Schultz, Janine; Siller, Nelly; Fleischer, Vinzenz; Bellenberg, Barbara; Berthele, Achim; Biberacher, Viola; Havla, Joachim; Hecker, Michael; Hohlfeld, Reinhard; Infante-Duarte, Carmen; Kirschke, Jan S; Kümpfel, Tania; Linker, Ralf; Paul, Friedemann; Pfeuffer, Steffen; Sämann, Philipp; Toenges, Gerrit; Weber, Frank; Zettl, Uwe K; Jahn-Eimermacher, Antje; Antony, Gisela; Groppa, Sergiu; Wiendl, Heinz; Hemmer, Bernh...     »
Abstract:
BACKGROUND: The course of multiple sclerosis (MS) shows substantial inter-individual variability. The underlying determinants of disease severity likely involve genetic and environmental factors. OBJECTIVE: The aim of this study was to assess the impact of APOE and HLA polymorphisms as well as smoking and body mass index (BMI) in the very early MS course. METHODS: Untreated patients ( n = 263) with a recent diagnosis of relapsing-remitting (RR) MS or clinically isolated syndrome underwent standa...     »
Zeitschriftentitel:
Mult Scler
Jahr:
2019
Band / Volume:
25
Heft / Issue:
5
Seitenangaben Beitrag:
661-668
Sprache:
eng
Volltext / DOI:
doi:10.1177/1352458518763541
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29532745
Print-ISSN:
1352-4585
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer); Neurologische Klinik und Poliklinik
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