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Title:

Repulsive Backbone-Backbone Interactions Modulate Access to Specific and Unspecific Binding Sites on Surface-Bound Mucins

Document type:
Zeitschriftenaufsatz
Author(s):
Lutz, Theresa; Marczynski, Matthias; Grill, Maximilian; Wall, Wolfgang A.; Lieleg, Oliver
Abstract:
Mucin glycoproteins are the matrix-forming key components of mucus, the innate protective barrier protecting us from pathogenic attack. However, this barrier is constantly challenged by mucin-degrading enzymes, which tend to target anionic glycan chains such as sulfate groups and sialic acid residues. Here, we demonstrate that the efficiency of both unspecific and specific binding of small molecules to mucins is reduced when sulfate groups are enzymatically removed from mucins; this is unexpect...     »
Keywords:
Anions,Peptides and proteins,Carbohydrates,Genetics,Molecules
Dewey Decimal Classification:
620 Ingenieurwissenschaften
Journal title:
Langmuir
Year:
2020
Year / month:
2020-10
Pages contribution:
36, 43, 12973–12982
Covered by:
Scopus; Web of Science
Language:
en
Fulltext / DOI:
doi:10.1021/acs.langmuir.0c02256
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33090801
WWW:
https://pubs.acs.org/doi/10.1021/acs.langmuir.0c02256#
Status:
Verlagsversion / published
Submitted:
17.04.2020
Date of publication:
22.10.2020
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