In this work we show that nearly complete eradication of the gut microbiota has the potential to ameliorate the severity of the AP. The mechanisms remain to be further elucidated, but our data presents a strong case for the communication between the gut and the pancreas in which absence of microbiota leads to a milder immune response upon AP induction. Additionally, we were able to show that certain bacterial strains translocated to the pancreas, and that they provoke an immune reaction in the pancreas.     «

In this work we show that nearly complete eradication of the gut microbiota has the potential to ameliorate the severity of the AP. The mechanisms remain to be further elucidated, but our data presents a strong case for the communication between the gut and the pancreas in which absence of microbiota leads to a milder immune response upon AP induction. Additionally, we were able to show that certain bacterial strains translocated to the pancreas, and that they provoke an immune reaction in the p...     »