In the current study, mRNA expression levels of KLK4, 5, 7 and 12 were investigated in tumor tissues of two patient cohorts, either afflicted with advanced high-grade serous ovarian cancer (HGSOC) or triple-negative breast cancer (TNBC). Together with available KLK5 and KLK7 protein data from a previous study, coordinate expression was observed between KLK5 and KLK7 in both entities. Moreover, elevated KLK4 and KLK7 mRNA levels were found to represent independent unfavorable prognostic biomarkers in HGSOC, while elevated KLK12 mRNA expression was independently related to worse prognosis in TNBC.
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In the current study, mRNA expression levels of KLK4, 5, 7 and 12 were investigated in tumor tissues of two patient cohorts, either afflicted with advanced high-grade serous ovarian cancer (HGSOC) or triple-negative breast cancer (TNBC). Together with available KLK5 and KLK7 protein data from a previous study, coordinate expression was observed between KLK5 and KLK7 in both entities. Moreover, elevated KLK4 and KLK7 mRNA levels were found to represent independent unfavorable prognostic biomarker...
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