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Title:

Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus.

Document type:
Article; Journal Article
Author(s):
Breuer, Johanna; Korpos, Eva; Hannocks, Melanie-Jane; Schneider-Hohendorf, Tilman; Song, Jian; Zondler, Lisa; Herich, Sebastian; Flanagan, Ken; Korn, Thomas; Zarbock, Alexander; Kuhlmann, Tanja; Sorokin, Lydia; Wiendl, Heinz; Schwab, Nicholas
Abstract:
BACKGROUND: Very late antigen 4 (VLA-4; integrin α4β1) is critical for transmigration of T helper (TH) 1 cells into the central nervous system (CNS) under inflammatory conditions such as multiple sclerosis (MS). We have previously shown that VLA-4 and melanoma cell adhesion molecule (MCAM) are important for trans-endothelial migration of human TH17 cells in vitro and here investigate their contribution to pathogenic CNS inflammation. METHODS: Antibody blockade of VLA-4 and MCAM is assessed in m...     »
Journal title abbreviation:
J Neuroinflammation
Year:
2018
Journal volume:
15
Journal issue:
1
Fulltext / DOI:
doi:10.1186/s12974-018-1276-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30134924
Print-ISSN:
1742-2094
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik
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