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Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kaisar, Maria M M; Ritter, Manuel; del Fresno, Carlos; Jónasdóttir, Hulda S; van der Ham, Alwin J; Pelgrom, Leonard R; Schramm, Gabriele; Layland, Laura E; Sancho, David; Prazeres da Costa, Clarissa; Giera, Martin; Yazdanbakhsh, Maria; Everts, Bart
Title:
Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.
Abstract:
The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain incompletely understood. Here, we report that soluble egg antigen (SEA) from Schistosoma mansoni, which is well known to drive potent Th2 responses, triggers DCs to produce prostaglandin E2 (PGE2), which subsequently-in an autocrine manner-induces OX40 ligand (OX40L) expression to license these DCs to drive Th2 responses. Mechanistically, SEA was...    »
Journal title abbreviation:
PLoS Biol
Year:
2018
Journal volume:
16
Journal issue:
4
Print-ISSN:
1544-9173
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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