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Document type:
Journal Article
Author(s):
Rataj, Felicitas; Kraus, Fabian B T; Chaloupka, Michael; Grassmann, Simon; Heise, Constanze; Cadilha, Bruno L; Duewell, Peter; Endres, Stefan; Kobold, Sebastian
Title:
PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma.
Abstract:
Interaction of the programmed death receptor 1 (PD-1) and its ligand, PD-L1, suppresses T cell activity and permits tumors to evade T cell-mediated immune surveillance. We have recently demonstrated that antigen-specific CD8+ T cells transduced with a PD1-CD28 fusion protein are protected from PD-1-mediated inhibition. We have now investigated the potential of PD1-CD28 fusion protein-transduced CD4+ T cells alone or in combination with CD8+ T cells for immunotherapy of pancreatic cancer and non...    »
Journal title abbreviation:
Front Immunol
Year:
2018
Journal volume:
9
Pages contribution:
1955
Fulltext / DOI:
doi:10.3389/fimmu.2018.01955
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30214445
Print-ISSN:
1664-3224
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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