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Titel:

A concise discussion of the regulatory role of cGMP kinase I in cardiac physiology and pathology.

Dokumenttyp:
Review; Journal Article; Review
Autor(en):
Hofmann, Franz
Abstract:
The underlying cause of cardiac hypertrophy, fibrosis, and heart failure has been investigated in great detail using different mouse models. These studies indicated that cGMP and cGMP-dependent protein kinase type I (cGKI) may ameliorate these negative phenotypes in the adult heart. Recently, evidence has been published that cardiac mitochondrial BKCa channels are a target for cGKI and that activation of mitoBKCa channels may cause some of the positive effects of conditioning in ischemia/reperfu...     »
Zeitschriftentitel:
Basic Res Cardiol
Jahr:
2018
Band / Volume:
113
Heft / Issue:
4
Volltext / DOI:
doi:10.1007/s00395-018-0690-1
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29934662
Print-ISSN:
0300-8428
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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