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Title:

H19 Induces Abdominal Aortic Aneurysm Development and Progression.

Document type:
Article; Journal Article
Author(s):
Li, Daniel Y; Busch, Albert; Jin, Hong; Chernogubova, Ekaterina; Pelisek, Jaroslav; Karlsson, Joakim; Sennblad, Bengt; Liu, Shengliang; Lao, Shen; Hofmann, Patrick; Bäcklund, Alexandra; Eken, Suzanne M; Roy, Joy; Eriksson, Per; Dacken, Brian; Ramanujam, Deepak; Dueck, Anne; Engelhardt, Stefan; Boon, Reinier A; Eckstein, Hans-Henning; Spin, Joshua M; Tsao, Philip S; Maegdefessel, Lars
Abstract:
BACKGROUND: Long noncoding RNAs have emerged as critical molecular regulators in various biological processes and diseases. Here we sought to identify and functionally characterize long noncoding RNAs as potential mediators in abdominal aortic aneurysm development. METHODS: We profiled RNA transcript expression in 2 murine abdominal aortic aneurysm models, Angiotensin II (ANGII) infusion in apolipoprotein E-deficient ( ApoE-/-) mice (n=8) and porcine pancreatic elastase instillation in C57BL/6 w...     »
Journal title abbreviation:
Circulation
Year:
2018
Journal volume:
138
Journal issue:
15
Pages contribution:
1551-1568
Fulltext / DOI:
doi:10.1161/CIRCULATIONAHA.117.032184
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29669788
Print-ISSN:
0009-7322
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein); Institut für Pharmakologie und Toxikologie
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