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Titel:

Shaping the humoral immune response: Actin regulators modulate antigen presentation and influence B-T interactions.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't; Review
Autor(en):
Burbage, Marianne; Keppler, Selina Jessica
Abstract:
B cells are an integral part of the adaptive immune system. During an immune response, the actin cytoskeleton plays a central role in regulating B cell antigen uptake, polarization and presentation as well as B cell migration and interaction with T cells. Genetic defects affecting actin regulators can result in reduced B cell activation, limited antibody production and hence cause disease. In this review, we discuss molecular mechanisms of actin regulation and their involvement in antigen polari...     »
Zeitschriftentitel:
Mol Immunol
Jahr:
2018
Band / Volume:
101
Seitenangaben Beitrag:
370-376
Volltext / DOI:
doi:10.1016/j.molimm.2018.07.026
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30055407
Print-ISSN:
0161-5890
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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