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Titel:

A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency.

Dokumenttyp:
Journal Article; Journal Article
Autor(en):
Stern, Daniel; Weisemann, Jasmin; Le Blanc, Alexander; von Berg, Laura; Mahrhold, Stefan; Piesker, Janett; Laue, Michael; Luppa, Peter B; Dorner, Martin Bernhard; Dorner, Brigitte Gertrud; Rummel, Andreas
Abstract:
The exceptional toxicity of botulinum neurotoxins (BoNTs) is mediated by high avidity binding to complex polysialogangliosides and intraluminal segments of synaptic vesicle proteins embedded in the presynaptic membrane. One peculiarity is an exposed hydrophobic loop in the toxin's cell binding domain HC, which is located between the ganglioside- and protein receptor-binding sites, and that is particularly pronounced in the serotypes BoNT/B, DC, and G sharing synaptotagmin as protein receptor. He...     »
Zeitschriftentitel:
PLoS Pathog
Jahr:
2018
Band / Volume:
14
Heft / Issue:
5
Seitenangaben Beitrag:
e1007048
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.ppat.1007048
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29718991
Print-ISSN:
1553-7366
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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