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Titel:

A simple and highly sensitive on-line column extraction liquid chromatography-tandem mass spectrometry method for the determination of protein-unbound tacrolimus in human plasma samples.

Dokumenttyp:
Journal Article; Journal Article
Autor(en):
Bittersohl, Heike; Schniedewind, Björn; Christians, Uwe; Luppa, Peter B
Abstract:
Therapeutic drug monitoring (TDM) of the immunosuppressive drug tacrolimus is essential to avoid side effects and rejection of the allograft after transplantation. In the blood circulation, tacrolimus is largely located inside erythrocytes or bound to plasma proteins and less than 0.1% is protein-unbound (free). One basic principle of clinical pharmacology is that only free drug is pharmacologically active and monitoring this portion has the potential to better reflect the drug effect than conve...     »
Zeitschriftentitel:
J Chromatogr A
Jahr:
2018
Band / Volume:
1547
Seitenangaben Beitrag:
45-52
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.chroma.2018.03.010
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29544893
Print-ISSN:
0021-9673
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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