Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative.

Neumann, Jan; Hofmann, Felix C; Heilmeier, Ursula; Ashmeik, Walid; Tang, Kenneth; Gersing, Alexandra S; Schwaiger, Benedikt J; Nevitt, Michael C; Joseph, Gabby B; Lane, Nancy E; McCulloch, Charles E; Link, Thomas M

doi:10.1016/j.joca.2018.03.010

Benutzer: Gast

Medizin

Zurück
Zurück zum Anfang der Trefferliste
Dauerhafter Link zum angezeigten Objekt

Titel:: Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative.
Dokumenttyp:: Journal Article
Autor(en):: Neumann, Jan; Hofmann, Felix C; Heilmeier, Ursula; Ashmeik, Walid; Tang, Kenneth; Gersing, Alexandra S; Schwaiger, Benedikt J; Nevitt, Michael C; Joseph, Gabby B; Lane, Nancy E; McCulloch, Charles E; Link, Thomas M
Abstract:: PURPOSE: Osteoarthritis (OA) and diabetes mellitus (DM) share common risk factors with a potential underlying relationship between both diseases. The purpose of this study was to investigate the longitudinal effects of DM on cartilage deterioration over 24-months with MR-based T2 relaxation time measurements. METHODS: From the Osteoarthritis Initiative (OAI) cohort 196 diabetics were matched in small sets for age, sex, BMI and Kellgren-Lawrence score with 196 non-diabetic controls. Knee cartilage semi-automatic segmentation was performed on 2D multi-slice multi-echo spin-echo sequences. Texture of cartilage T2 maps was obtained via grey level co-occurrence matrix analysis. Linear regression analysis was used to compare cross-sectional and changes in T2 and texture parameters between the groups. RESULTS: Both study groups were similar in age (63.3 vs 63.0 years, P = 0.70), BMI (30.9 vs 31.2 kg/m2, P = 0.52), sex (female 53.6% vs 54.1%, P = 0.92) and KL score distribution (P = 0.97). In diabetics, except for the patella, all compartments showed a significantly higher increase in mean T2 values when compared to non-diabetic controls. Global T2 values increased almost twice as much; 1.77ms vs 0.98ms (0.79ms [CI: 0.39,1.19]) (P < 0.001). Additionally, global T2 values showed a significantly higher increase in the bone layer (P = 0.006), and in a separate analysis of the texture parameters, diabetics also showed consistently higher texture values (P < 0.05), indicating a more disordered cartilage composition. CONCLUSION: Cartilage T2 values in diabetics show a faster increase with a consistently more heterogeneous cartilage texture composition. DM seems to be a risk factor for developing early OA with an accelerated degeneration of the articular cartilage in the knee.
Zeitschriftentitel:: Osteoarthritis Cartilage
Jahr:: 2018
Band / Volume:: 26
Heft / Issue:: 6
Seitenangaben Beitrag:: 751-761
Volltext / DOI:: doi:10.1016/j.joca.2018.03.010
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/29605381
Print-ISSN:: 1063-4584
TUM Einrichtung:: Institut für Diagnostische und Interventionelle Radiologie
BibTeX