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Title:

Characterization of noise in multistable genetic circuits reveals ways to modulate heterogeneity

Document type:
Zeitschriftenaufsatz
Author(s):
Sayuri K. Hortsch, Andreas Kremling
Abstract:
Random fluctuations in the amount of cellular components like mRNA and protein molecules are inevitable due to the stochastic and discrete nature of biochemical reactions. If large enough, this so-called “cellular noise” can lead to random transitions between the expression states of a multistable genetic circuit. That way, heterogeneity within isogenic populations is created. Our aim is to understand which dynamical features of a simple autoregulatory system determine its intrinsic noise level,...     »
Journal title:
PLOS One
Year:
2018
Covered by:
Scopus; Web of Science
Language:
en
Fulltext / DOI:
doi:10.1371/journal.pone.0194779
WWW:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194779
Date of publication:
26.03.2018
TUM Institution:
Professur für Systembiotechnologie
Ingested:
11.04.2018
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