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- Original title:
- Untersuchung oxidativer Funktionalisierungsreaktionen in der Biosynthese mikrobieller Peptidnaturstoffe
- Translated title:
- Investigation of oxidative functionalizing reactions in the biosynthesis of microbial peptide natural products
- Author:
- Richarz, René
- Year:
- 2018
- Document type:
- Dissertation
- Faculty/School:
- Fakultät für Chemie
- Advisor:
- Gulder, Tobias A. M. (Prof. Dr.)
- Referee:
- Gulder, Tobias A. M. (Prof. Dr.); Sieber, Stephan A. (Prof. Dr.)
- Language:
- de
- Subject group:
- CHE Chemie
- TUM classification:
- CHE 800d
- Abstract:
- Biarylhaltige Peptidnaturstoffe sind interessante Ziele für die Entwicklung neuer Arzneimittel. Ihre chemische Synthese wird jedoch durch die Installation der strukturgebenden Biarylbindungen erschwert. Die vorliegende Arbeit beschreibt die Entwicklung eines Systems für die Totalsynthese von Complestatin und Cittilin A, das auf den Cytochrom P450-Enzymen basiert, welche die jeweiligen Biarylkupplungen in der Natur vermitteln. Weiterhin werden Untersuchungen zur Biosynthese der biarylhaltigen Bip... »
- Translated abstract:
- Biaryl-containing peptide natural products are interesting targets for the development of new pharmaceuticals. However, their chemical synthesis is hampered by the installation of the structurally decisive biaryl bonds. In this thesis, the development of a system for the total synthesis of complestatin and cittlin A is presented, which is based on the cytochrome P450 enzymes catalyzing the respective biaryl-couplings in nature. In addition, investigations on the biosynthesis of the biaryl-contai... »
- WWW:
- https://mediatum.ub.tum.de/?id=1405847
- Date of submission:
- 06.12.2017
- Oral examination:
- 16.02.2018
- File size:
- 9521789 bytes
- Pages:
- 230
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20180216-1405847-1-7
- Last change:
- 01.12.2019
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