Biosynthetic pathways are nature’s route maps to diverse classes of natural products and an understanding of these pathways is crucial for the discovery of new and effective medicines to combat disease and overcome drug resistance. This thesis gives structural and mechanistic insights into the logic of type II polyketide synthases (PKSs) at the level of protein-protein interactions and into a member of the key tailoring and maturation catalysts in all natural product classes, namely oxygenases, both of vital importance for fundamental enzymology and medicinal purposes.      «

Biosynthetic pathways are nature’s route maps to diverse classes of natural products and an understanding of these pathways is crucial for the discovery of new and effective medicines to combat disease and overcome drug resistance. This thesis gives structural and mechanistic insights into the logic of type II polyketide synthases (PKSs) at the level of protein-protein interactions and into a member of the key tailoring and maturation catalysts in all natural product classes, namely oxygenases,...     »