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Title:

Long-term pre- and postconditioning with low doses of erythropoietin protects critically perfused musculocutaneous tissue from necrosis.

Document type:
Journal Article
Author(s):
Schmauss, Daniel; Weinzierl, Andrea; Weiss, Fabian; Egaña, José T; Rezaeian, Farid; Hopfner, Ursula; Schmauss, Verena; Machens, Hans-Günther; Harder, Yves
Abstract:
It has been shown that pre- and postconditioning of ischemically challenged tissue with erythropoietin (EPO) is able to reduce necrosis in a dose-dependent manner. The aim of this study was to determine the tissue-protective effects of different EPO dosages and administration regimes. Three groups of six C57Bl/6-mice each were analyzed: (1) pre- and postconditioning with initial high doses of EPO (starting at 2500 I.U./kg bw i.p.) followed by low doses of EPO (125 I.U./kg bw i.p.) (EPO-high-dose...     »
Journal title abbreviation:
J Plast Reconstr Aesthet Surg
Year:
2019
Journal volume:
72
Journal issue:
4
Pages contribution:
590-599
Fulltext / DOI:
doi:10.1016/j.bjps.2019.01.003
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30733080
Print-ISSN:
1748-6815
TUM Institution:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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