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Title:

Microvesicles from human adipose stem cells promote wound healing by optimizing cellular functions via AKT and ERK signaling pathways.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Ren, Sen; Chen, Jing; Duscher, Dominik; Liu, Yutian; Guo, Guojun; Kang, Yu; Xiong, Hewei; Zhan, Peng; Wang, Yang; Wang, Cheng; Machens, Hans-Günther; Chen, Zhenbing
Abstract:
BACKGROUND: Human adipose stem cells (ASCs) have emerged as a promising treatment paradigm for skin wounds. Recent works demonstrate that the therapeutic effect of stem cells is partially mediated by extracellular vesicles, which comprise exosomes and microvesicles. In this study, we investigate the regenerative effects of isolated microvesicles from ASCs and evaluate the mechanisms how ASC microvesicles promote wound healing. METHODS: Adipose stem cell-derived microvesicles (ASC-MVs) were isola...     »
Journal title abbreviation:
Stem Cell Res Ther
Year:
2019
Journal volume:
10
Journal issue:
1
Fulltext / DOI:
doi:10.1186/s13287-019-1152-x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30704535
TUM Institution:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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