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- Document type:
- Journal Article; Research Support, Non-U.S. Gov't; Comment
- Author(s):
- Ruland, Jürgen
- Title:
- Colon Cancer: Epithelial Notch Signaling Recruits Neutrophils to Drive Metastasis.
- Abstract:
- In this issue of Cancer Cell, Jackstadt et al. report that pathological Notch signaling in colorectal cancer (CRC) cells can initiate a neutrophil-dependent, TGF-β-mediated cascade that leads to metastatic disease. Inhibition of this pathway with clinically relevant compounds blocks metastatic spread in a developed murine model of CRC.
- Journal title abbreviation:
- Cancer Cell
- Year:
- 2019
- Journal volume:
- 36
- Journal issue:
- 3
- Pages contribution:
- 213-214
- Fulltext / DOI:
- doi:10.1016/j.ccell.2019.08.010
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/31526756
- Print-ISSN:
- 1535-6108
- TUM Institution:
- Institut für Klinische Chemie und Pathobiochemie
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