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Title:

Colon Cancer: Epithelial Notch Signaling Recruits Neutrophils to Drive Metastasis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Comment
Author(s):
Ruland, Jürgen
Abstract:
In this issue of Cancer Cell, Jackstadt et al. report that pathological Notch signaling in colorectal cancer (CRC) cells can initiate a neutrophil-dependent, TGF-β-mediated cascade that leads to metastatic disease. Inhibition of this pathway with clinically relevant compounds blocks metastatic spread in a developed murine model of CRC.
Journal title abbreviation:
Cancer Cell
Year:
2019
Journal volume:
36
Journal issue:
3
Pages contribution:
213-214
Fulltext / DOI:
doi:10.1016/j.ccell.2019.08.010
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31526756
Print-ISSN:
1535-6108
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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