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Title:

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Jordão, Marta Joana Costa; Sankowski, Roman; Brendecke, Stefanie M; Sagar; Locatelli, Giuseppe; Tai, Yi-Heng; Tay, Tuan Leng; Schramm, Eva; Armbruster, Stephan; Hagemeyer, Nora; Groß, Olaf; Mai, Dominic; Çiçek, Özgün; Falk, Thorsten; Kerschensteiner, Martin; Grün, Dominic; Prinz, Marco
Abstract:
The innate immune cell compartment is highly diverse in the healthy central nervous system (CNS), including parenchymal and non-parenchymal macrophages. However, this complexity is increased in inflammatory settings by the recruitment of circulating myeloid cells. It is unclear which disease-specific myeloid subsets exist and what their transcriptional profiles and dynamics during CNS pathology are. Combining deep single-cell transcriptome analysis, fate mapping, in vivo imaging, clonal analysis...     »
Journal title abbreviation:
Science
Year:
2019
Journal volume:
363
Journal issue:
6425
Fulltext / DOI:
doi:10.1126/science.aat7554
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30679343
Print-ISSN:
0036-8075
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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