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Titel:

Colon Cancer: Epithelial Notch Signaling Recruits Neutrophils to Drive Metastasis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Comment
Autor(en):
Ruland, Jürgen
Abstract:
In this issue of Cancer Cell, Jackstadt et al. report that pathological Notch signaling in colorectal cancer (CRC) cells can initiate a neutrophil-dependent, TGF-β-mediated cascade that leads to metastatic disease. Inhibition of this pathway with clinically relevant compounds blocks metastatic spread in a developed murine model of CRC.
Zeitschriftentitel:
Cancer Cell
Jahr:
2019
Band / Volume:
36
Heft / Issue:
3
Seitenangaben Beitrag:
213-214
Volltext / DOI:
doi:10.1016/j.ccell.2019.08.010
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31526756
Print-ISSN:
1535-6108
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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