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Titel:

Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Steinbach, Karin; Vincenti, Ilena; Egervari, Kristof; Kreutzfeldt, Mario; van der Meer, Franziska; Page, Nicolas; Klimek, Bogna; Rossitto-Borlat, Irène; Di Liberto, Giovanni; Muschaweckh, Andreas; Wagner, Ingrid; Hammad, Karim; Stadelmann, Christine; Korn, Thomas; Hartley, Oliver; Pinschewer, Daniel D; Merkler, Doron
Abstract:
Epidemiological studies associate viral infections during childhood with the risk of developing autoimmune disease during adulthood. However, the mechanistic link between these events remains elusive. We report that transient viral infection of the brain in early life, but not at a later age, precipitates brain autoimmune disease elicited by adoptive transfer of myelin-specific CD4+ T cells at sites of previous infection in adult mice. Early-life infection of mouse brains imprinted a chronic inf...     »
Zeitschriftentitel:
Sci Transl Med
Jahr:
2019
Band / Volume:
11
Heft / Issue:
498
Volltext / DOI:
doi:10.1126/scitranslmed.aav5519
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31243152
Print-ISSN:
1946-6234
TUM Einrichtung:
Molekulare Immunologie (Prof. Knolle)
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