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Title:

Stability and Maintenance of Foxp3+ Treg Cells in Non-lymphoid Microenvironments.

Document type:
Review; Journal Article; Review
Author(s):
Korn, Thomas; Muschaweckh, Andreas
Abstract:
Foxp3+ Treg cells are indispensable for maintaining self-tolerance in secondary lymphoid organs (SLOs). However, Treg cells are also recruited to non-lymphoid tissues (NLTs) during inflammation. Recent advances in the understanding of Treg cell biology provided us with molecular mechanisms-both transcriptional and epigenetic-that enable Treg cells to retain their identity in an inflammatory milieu that is per se hostile to sustained expression of high levels of Foxp3. While Treg cells are recrui...     »
Journal title abbreviation:
Front Immunol
Year:
2019
Journal volume:
10
Fulltext / DOI:
doi:10.3389/fimmu.2019.02634
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31798580
Print-ISSN:
1664-3224
TUM Institution:
Molekulare Immunologie (Prof. Knolle)
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