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Title:

Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Steinbach, Karin; Vincenti, Ilena; Egervari, Kristof; Kreutzfeldt, Mario; van der Meer, Franziska; Page, Nicolas; Klimek, Bogna; Rossitto-Borlat, Irène; Di Liberto, Giovanni; Muschaweckh, Andreas; Wagner, Ingrid; Hammad, Karim; Stadelmann, Christine; Korn, Thomas; Hartley, Oliver; Pinschewer, Daniel D; Merkler, Doron
Abstract:
Epidemiological studies associate viral infections during childhood with the risk of developing autoimmune disease during adulthood. However, the mechanistic link between these events remains elusive. We report that transient viral infection of the brain in early life, but not at a later age, precipitates brain autoimmune disease elicited by adoptive transfer of myelin-specific CD4+ T cells at sites of previous infection in adult mice. Early-life infection of mouse brains imprinted a chronic inf...     »
Journal title abbreviation:
Sci Transl Med
Year:
2019
Journal volume:
11
Journal issue:
498
Fulltext / DOI:
doi:10.1126/scitranslmed.aav5519
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31243152
Print-ISSN:
1946-6234
TUM Institution:
Molekulare Immunologie (Prof. Knolle)
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