Stars Are Not in Outer Space: Astrocytes Respond to Environmental Cues.
Document type:
Editorial Material; Journal Article
Author(s):
Korn, Thomas
Abstract:
By in vivo screening in zebrafish larvae, Wheeler et al. identify environmental agents that directly modulate transcriptional programs of astrocytes. The herbicide linuron exploits the unfolded protein response pathway to induce a pro-inflammatory program in reactive astrocytes that potentiates inflammatory tissue damage in the CNS.