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Title:

Detection and kinetics of persistent neutralizing anti-interferon-beta antibodies in patients with multiple sclerosis. Results from the ABIRISK prospective cohort study.

Document type:
Journal Article
Author(s):
Jensen, Poul Erik H; Warnke, Clemens; Ingenhoven, Kathleen; Piccoli, Luca; Gasis, Marcia; Hermanrud, Christina; Fernandez-Rodriguez, Blanca M; Ryner, Malin; Kramer, Daniel; Link, Jenny; Ramanujam, Ryan; Auer, Michael; Buck, Dorothea; Grummel, Verena; Bertotti, Elisa; Fissolo, Nicolas; Oliver-Martos, Begoña; Nytrova, Petra; Khalil, Michael; Guger, Michael; Rathmaier, Sandra; Sievers-Stober, Claudia; Lindberg, Raija L P; Hässler, Signe; Bachelet, Delphine; Aktas, Orhan; Donnellan, Naoimh; Lawton,...     »
Abstract:
Two validated assays, a bridging ELISA and a luciferase-based bioassay, were compared for detection of anti-drug antibodies (ADA) against interferon-beta (IFN-β) in patients with multiple sclerosis. Serum samples were tested from patients enrolled in a prospective study of 18 months. In contrast to the ELISA, when IFN-β-specific rabbit polyclonal and human monoclonal antibodies were tested, the bioassay was the more sensitive to detect IFN-β ADA in patients' sera. For clinical samples, selection...     »
Journal title abbreviation:
J Neuroimmunol
Year:
2019
Journal volume:
326
Pages contribution:
19-27
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jneuroim.2018.11.002
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30447419
Print-ISSN:
0165-5728
TUM Institution:
Neurologische Klinik und Poliklinik
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