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Title:

Effect of HLA-DRB1 alleles and genetic variants on the development of neutralizing antibodies to interferon beta in the BEYOND and BENEFIT trials.

Document type:
Journal Article
Author(s):
Buck, Dorothea; Andlauer, Till Fm; Igl, Wilmar; Wicklein, Eva-Maria; Mühlau, Mark; Weber, Frank; Köchert, Karl; Pohl, Christoph; Arnason, Barry; Comi, Giancarlo; Cook, Stuart; Filippi, Massimo; Hartung, Hans-Peter; Jeffery, Douglas; Kappos, Ludwig; Barkhof, Frederik; Edan, Gilles; Freedman, Mark S; Montalban, Xavier; Müller-Myhsok, Bertram; Hemmer, Bernhard
Abstract:
BACKGROUND: Treatment of multiple sclerosis (MS) with interferon β can lead to the development of antibodies directed against interferon β that interfere with treatment efficacy. Several observational studies have proposed different HLA alleles and genetic variants associated with the development of antibodies against interferon β. OBJECTIVE: To validate the proposed genetic markers and to identify new markers. METHODS: Associations of genetic candidate markers with antibody presence and develop...     »
Journal title abbreviation:
Mult Scler
Year:
2019
Journal volume:
25
Journal issue:
4
Pages contribution:
565-573
Language:
eng
Fulltext / DOI:
doi:10.1177/1352458518763089
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29521573
Print-ISSN:
1352-4585
TUM Institution:
Neurologische Klinik und Poliklinik
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