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Titel:

Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation.

Dokumenttyp:
Journal Article
Autor(en):
Wheeler, Michael A; Jaronen, Merja; Covacu, Ruxandra; Zandee, Stephanie E J; Scalisi, Giulia; Rothhammer, Veit; Tjon, Emily C; Chao, Chun-Cheih; Kenison, Jessica E; Blain, Manon; Rao, Vijayaraghava T S; Hewson, Patrick; Barroso, Andreia; Gutiérrez-Vázquez, Cristina; Prat, Alexandre; Antel, Jack P; Hauser, Russ; Quintana, Francisco J
Abstract:
Genome-wide studies have identified genetic variants linked to neurologic diseases. Environmental factors also play important roles, but no methods are available for their comprehensive investigation. We developed an approach that combines genomic data, screens in a novel zebrafish model, computational modeling, perturbation studies, and multiple sclerosis (MS) patient samples to evaluate the effects of environmental exposure on CNS inflammation. We found that the herbicide linuron amplifies ast...     »
Zeitschriftentitel:
Cell
Jahr:
2019
Band / Volume:
176
Heft / Issue:
3
Seitenangaben Beitrag:
581-596.e18
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.cell.2018.12.012
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30661753
Print-ISSN:
0092-8674
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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