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Title:

Interleukin-6: designing specific therapeutics for a complex cytokine.

Document type:
Review; Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Garbers, Christoph; Heink, Sylvia; Korn, Thomas; Rose-John, Stefan
Abstract:
Interleukin-6 (IL-6) is a pivotal cytokine with a diverse repertoire of physiological functions that include regulation of immune cell proliferation and differentiation. Dysregulation of IL-6 signalling is associated with inflammatory and lymphoproliferative disorders such as rheumatoid arthritis and Castleman disease, and several classes of therapeutics have been developed that target components of the IL-6 signalling pathway. So far, monoclonal antibodies against IL-6 or IL-6 receptor (IL-6R)...     »
Journal title abbreviation:
Nat Rev Drug Discov
Year:
2018
Journal volume:
17
Journal issue:
6
Pages contribution:
395-412
Fulltext / DOI:
doi:10.1038/nrd.2018.45
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29725131
Print-ISSN:
1474-1776
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik
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