Plasma Levels of Soluble AβPPβ as a Biomarker for Alzheimer's Disease with Dementia.

Alexopoulos, Panagiotis; Thierjung, Nathalie; Economou, Polychronis; Werle, Lukas; Buhl, Felix; Kagerbauer, Simone; Papanastasiou, Anastasios D; Grimmer, Timo; Gourzis, Philippos; Berthele, Achim; Hemmer, Bernhard; Kübler, Hubert; Martin, Jan; Politis, Antonios; Perneczky, Robert

doi:10.3233/JAD-181088

2019

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Title:: Plasma Levels of Soluble AβPPβ as a Biomarker for Alzheimer's Disease with Dementia.
Document type:: Article; Journal Article
Author(s):: Alexopoulos, Panagiotis; Thierjung, Nathalie; Economou, Polychronis; Werle, Lukas; Buhl, Felix; Kagerbauer, Simone; Papanastasiou, Anastasios D; Grimmer, Timo; Gourzis, Philippos; Berthele, Achim; Hemmer, Bernhard; Kübler, Hubert; Martin, Jan; Politis, Antonios; Perneczky, Robert
Abstract:: Cost- and time-effective markers of Alzheimer's disease (AD), reliable and feasible at the population level are urgently needed. Soluble amyloid-β protein precursor β (sAβPPβ) in plasma has attracted scientific attention as a potential AD biomarker candidate. Here we report that plasma sAβPPβ levels in patients with AD dementia and typical for AD cerebrospinal fluid (CSF) biomarker profiles (N = 33) are significantly lower (p < 0.01) than those of cognitively healthy elderly individuals without AD (N = 39), while CSF sAβPPβ levels did not differ between the studied groups. This provides further evidence for the potential of sAβPPβ in plasma as an AD biomarker candidate.
Journal title abbreviation:: J Alzheimers Dis
Year:: 2019
Journal volume:: 69
Journal issue:: 1
Pages contribution:: 83-90
Fulltext / DOI:: doi:10.3233/JAD-181088
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/30909232
Print-ISSN:: 1387-2877
TUM Institution:: Klinik für Anästhesiologie (DHM); Klinik und Poliklinik für Psychiatrie und Psychotherapie; Neurologische Klinik und Poliklinik
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