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Title:

Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer's Disease.

Document type:
Journal Article
Author(s):
Grimmer, Timo; Goldhardt, Oliver; Yakushev, Igor; Ortner, Marion; Sorg, Christian; Diehl-Schmid, Janine; Förstl, Hans; Kurz, Alexander; Perneczky, Robert; Miners, Scott
Abstract:
BACKGROUND: Neprilysin (NEP) cleaves amyloid-β 1-42 (Aβ42) in the brain. Hence, we aimed to elucidate the effect of NEP on Aβ42 in cerebrospinal fluid (CSF) and on in vivo brain amyloid load using amyloid positron emission tomography (PET) with [11C]PiB (Pittsburgh compound B). In addition, associations with the biomarkers for neuronal injury, CSF-tau and FDG-PET, were investigated. METHODS: Associations were calculated using global and voxel-based (SPM8) linear regression analyses in the same c...     »
Journal title abbreviation:
Neurodegener Dis
Year:
2019
Journal volume:
19
Journal issue:
1
Pages contribution:
43-50
Fulltext / DOI:
doi:10.1159/000500811
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31266021
Print-ISSN:
1660-2854
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer); Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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