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- Document type:
- Article; Journal Article; Research Support, Non-U.S. Gov't
- Author(s):
- Oeckl, Patrick; Halbgebauer, Steffen; Anderl-Straub, Sarah; Steinacker, Petra; Huss, André M; Neugebauer, Hermann; von Arnim, Christine A F; Diehl-Schmid, Janine; Grimmer, Timo; Kornhuber, Johannes; Lewczuk, Piotr; Danek, Adrian; Ludolph, Albert C; Otto, Markus
- Title:
- Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment.
- Abstract:
- Reliable blood biomarkers for Alzheimer's disease (AD) are missing. We measured astroglial GFAP in patients with AD (n = 28), frontotemporal dementia (bvFTD, n = 35), Parkinson's disease (n = 11), Lewy body dementias (n = 19), and controls (n = 34). Serum GFAP was increased in AD (p < 0.001) and DLB/PDD (p < 0.01), and cerebrospinal fluid GFAP was increased in all neurodegenerative diseases (p < 0.001). Serum GFAP correlated with the Mini-Mental State Examination score (r= -0.42, p < 0.001) and might be a follow-up marker in clinical trials. Sensitivity and specificity of serum GFAP for AD versus bvFTD was 89% and 79% and might be the first blood biomarker in the differential diagnosis of AD and bvFTD.
- Journal title abbreviation:
- J Alzheimers Dis
- Year:
- 2019
- Journal volume:
- 67
- Journal issue:
- 2
- Pages contribution:
- 481-488
- Fulltext / DOI:
- doi:10.3233/JAD-180325
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/30594925
- Print-ISSN:
- 1387-2877
- TUM Institution:
- Klinik und Poliklinik für Psychiatrie und Psychotherapie
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