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Title:

Acute Skin Damage and Late Radiation-Induced Fibrosis and Inflammation in Murine Ears after High-Dose Irradiation.

Document type:
Article; Journal Article
Author(s):
Dombrowsky, Annique C; Schauer, Jannis; Sammer, Matthias; Blutke, Andreas; Walsh, Dietrich W M; Schwarz, Benjamin; Bartzsch, Stefan; Feuchtinger, Annette; Reindl, Judith; Combs, Stephanie E; Dollinger, Günther; Schmid, Thomas E
Abstract:
The use of different scoring systems for radiation-induced toxicity limits comparability between studies. We examined dose-dependent tissue alterations following hypofractionated X-ray irradiation and evaluated their use as scoring criteria. Four dose fractions (0, 5, 10, 20, 30 Gy/fraction) were applied daily to ear pinnae. Acute effects (ear thickness, erythema, desquamation) were monitored for 92 days after fraction 1. Late effects (chronic inflammation, fibrosis) and the presence of transfor...     »
Journal title abbreviation:
Cancers
Year:
2019
Journal volume:
11
Journal issue:
5
Fulltext / DOI:
doi:10.3390/cancers11050727
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31130616
Print-ISSN:
2072-6694
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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