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Title:

Application of variance-based uncertainty and sensitivity analysis to biological modeling in carbon ion treatment plans.

Document type:
Journal Article
Author(s):
Kamp, Florian; Wilkens, Jan J
Abstract:
PURPOSE: In ion beam therapy, biological models to estimate the relative biological effectiveness (RBE) and subsequently the RBE-weighted dose (RWD) are needed in treatment planning and plan evaluation. The required biological parameters as well as their dependency on ion species and ion energy can typically not be determined directly in experiments for in vivo situations. For that reason they are often derived from in vitro data and biological modeling and subject to large uncertainties. We pre...     »
Journal title abbreviation:
Med Phys
Year:
2019
Journal volume:
46
Journal issue:
2
Pages contribution:
437-447
Fulltext / DOI:
doi:10.1002/mp.13306
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30471124
Print-ISSN:
0094-2405
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
 BibTeX