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Title:

Regeneration After Radiation- and Immune-Mediated Tissue Injury Is Not Enhanced by Type III Interferon Signaling.

Document type:
Journal Article
Author(s):
Fischer, Julius C; Lin, Chia-Ching; Heidegger, Simon; Wintges, Alexander; Schlapschy, Martin; Beudert, Matthias; Combs, Stephanie E; Bassermann, Florian; Skerra, Arne; Haas, Tobias; Poeck, Hendrik
Abstract:
PURPOSE: Type I interferon (IFN-I) and interleukin (IL)-22 modulate regeneration of the thymus and intestinal epithelial cells (IECs) after cytotoxic stress such as irradiation. Radiation-induced damage to thymic tissues and IECs is a crucial aspect during the pathogenesis of inadequate immune reconstitution and acute graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with myeloablative total body irradiation (TBI), respectively. IL-22 and IFN-I...     »
Journal title abbreviation:
Int J Radiat Oncol Biol Phys
Year:
2019
Journal volume:
103
Journal issue:
4
Pages contribution:
970-976
Fulltext / DOI:
doi:10.1016/j.ijrobp.2018.11.038
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30503785
Print-ISSN:
0360-3016
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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