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Titel:

Application of variance-based uncertainty and sensitivity analysis to biological modeling in carbon ion treatment plans.

Dokumenttyp:
Journal Article
Autor(en):
Kamp, Florian; Wilkens, Jan J
Abstract:
PURPOSE: In ion beam therapy, biological models to estimate the relative biological effectiveness (RBE) and subsequently the RBE-weighted dose (RWD) are needed in treatment planning and plan evaluation. The required biological parameters as well as their dependency on ion species and ion energy can typically not be determined directly in experiments for in vivo situations. For that reason they are often derived from in vitro data and biological modeling and subject to large uncertainties. We pre...     »
Zeitschriftentitel:
Med Phys
Jahr:
2019
Band / Volume:
46
Heft / Issue:
2
Seitenangaben Beitrag:
437-447
Volltext / DOI:
doi:10.1002/mp.13306
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30471124
Print-ISSN:
0094-2405
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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