Atrioventricular valve regurgitation in patients undergoing total cavopulmonary connection: Impact of valve morphology and underlying mechanisms on survival and reintervention.

Ono, Masamichi; Cleuziou, Julie; Pabst von Ohain, Jelena; Beran, Elisabeth; Burri, Melchior; Strbad, Martina; Hager, Alfred; Hörer, Jürgen; Schreiber, Christian; Lange, Rüdiger

doi:10.1016/j.jtcvs.2017.08.122

journal article

Titel:: Atrioventricular valve regurgitation in patients undergoing total cavopulmonary connection: Impact of valve morphology and underlying mechanisms on survival and reintervention.
Dokumenttyp:: Journal Article; Article
Autor(en):: Ono, Masamichi; Cleuziou, Julie; Pabst von Ohain, Jelena; Beran, Elisabeth; Burri, Melchior; Strbad, Martina; Hager, Alfred; Hörer, Jürgen; Schreiber, Christian; Lange, Rüdiger
Abstract:: The study objective was to determine the mechanisms of atrioventricular valve regurgitation in single-ventricle physiology and their influence on outcomes after total cavopulmonary connection.Among 460 patients who underwent a total cavopulmonary connection, 101 (22%) had atrioventricular valve surgery before or coincident with total cavopulmonary connection.Atrioventricular valve morphology showed 2 separated in 33 patients, mitral in 11 patients, tricuspid in 41 patients, and common in 16 patients. Patients with a tricuspid and a common atrioventricular valve underwent atrioventricular valve surgery frequently, 27% and 36%, respectively. Atrioventricular valve regurgitation was due to 1 or more of the following mechanisms: dysplastic leaflet (62), prolapse (53), annular dilation (27), cleft (22), and chordal anomaly (14). Structural anomalies were observed in 89 patients (88%). The procedure was atrioventricular valve repair in 81 patients, atrioventricular valve closure in 16 patients, and atrioventricular valve replacement in 4 patients. Among 81 patients who underwent initial repair, repeat repair was required in 20 patients, atrioventricular valve replacement was required in 7 patients, and atrioventricular valve closure was required in 3 patients. Among patients undergoing atrioventricular valve surgery, overall survival after total cavopulmonary connection (88% vs 95% at 15 years, P = .01), freedom from atrioventricular valve reoperation after total cavopulmonary connection (75% vs 99% at 15 years, P < .01), and grade of atrioventricular valve regurgitation at a median follow-up of 6.6 years (P < .01) were worse than in those who did not require atrioventricular valve surgery.Atrioventricular valve regurgitation in univentricular heart is more frequently associated with a tricuspid or a common atrioventricular valve, and structural anomalies are the primary cause. Significant atrioventricular valve regurgitation requiring surgery influences survival after total cavopulmonary connection, especially when atrioventricular valve replacement was needed. Surgical management based on mechanisms of regurgitation is mandatory.
Zeitschriftentitel:: J Thorac Cardiovasc Surg
Jahr:: 2018
Band / Volume:: 155
Heft / Issue:: 2
Seitenangaben Beitrag:: 701-709.e6
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.jtcvs.2017.08.122
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/28992972
Print-ISSN:: 0022-5223
TUM Einrichtung:: Klinik für Herz- und Gefäßchirurgie (Prof. Lange)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Herz- und Gefäßchirurgie (DHM) (Prof. Krane)2018