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Title:

Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis.

Document type:
Journal Article; Article
Author(s):
Deutsch, Marcus-André; Doppler, Stefanie A; Li, Xinghai; Lahm, Harald; Santamaria, Gianluca; Cuda, Giovanni; Eichhorn, Stefan; Ratschiller, Thomas; Dzilic, Elda; Dreßen, Martina; Eckart, Annekathrin; Stark, Konstantin; Massberg, Steffen; Bartels, Anna; Rischpler, Christoph; Gilsbach, Ralf; Hein, Lutz; Fleischmann, Bernd K; Wu, Sean M; Lange, Rüdiger; Krane, Markus
Abstract:
The contribution of resident stem or progenitor cells to cardiomyocyte renewal after injury in adult mammalian hearts remains a matter of considerable debate. We evaluated a cell population in the adult mouse heart induced by myocardial infarction (MI) and characterized by an activated Nkx2.5 enhancer element that is specific for multipotent cardiac progenitor cells (CPCs) during embryonic development. We hypothesized that these MI-induced cells (MICs) harbour cardiomyogenic properties similar t...     »
Journal title abbreviation:
Cardiovasc Res
Year:
2018
Journal volume:
114
Journal issue:
8
Pages contribution:
1098-1114
Language:
eng
Fulltext / DOI:
doi:10.1093/cvr/cvy069
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29579159
Print-ISSN:
0008-6363
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); Klinik für Herz- und Gefäßchirurgie (Prof. Lange); Klinik und Poliklinik für Nuklearmedizin
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