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Titel:

Short-term retinoic acid treatment sustains pluripotency and suppresses differentiation of human induced pluripotent stem cells.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
De Angelis, Maria Teresa; Parrotta, Elvira Immacolata; Santamaria, Gianluca; Cuda, Giovanni
Abstract:
Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) derived from blastocyst and human induced pluripotent stem cells (hiPSCs) generated from somatic cells by ectopic expression of defined transcriptional factors, have both the ability to self-renew and to differentiate into all cell types. Here we explored the two antagonistic effects of retinoic acid (RA) on hiPSCs. Although RA has been widely described as a pharmacological agent with a critical role in initiating...     »
Zeitschriftentitel:
Cell Death Dis
Jahr:
2018
Band / Volume:
9
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41419-017-0028-1
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29305588
TUM Einrichtung:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin; I. Medizinische Klinik und Poliklinik (Kardiologie)
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