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Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
De Angelis, Maria Teresa; Parrotta, Elvira Immacolata; Santamaria, Gianluca; Cuda, Giovanni
Title:
Short-term retinoic acid treatment sustains pluripotency and suppresses differentiation of human induced pluripotent stem cells.
Abstract:
Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) derived from blastocyst and human induced pluripotent stem cells (hiPSCs) generated from somatic cells by ectopic expression of defined transcriptional factors, have both the ability to self-renew and to differentiate into all cell types. Here we explored the two antagonistic effects of retinoic acid (RA) on hiPSCs. Although RA has been widely described as a pharmacological agent with a critical role in initiating...     »
Journal title abbreviation:
Cell Death Dis
Year:
2018
Journal volume:
9
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41419-017-0028-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29305588
TUM Institution:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin; I. Medizinische Klinik und Poliklinik (Kardiologie)
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