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Title:

Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy.

Document type:
Journal Article; Article
Author(s):
Schick, Revital; Mekies, Lucy N; Shemer, Yuval; Eisen, Binyamin; Hallas, Tova; Ben Jehuda, Ronen; Ben-Ari, Meital; Szantai, Agnes; Willi, Lubna; Shulman, Rita; Gramlich, Michael; Pane, Luna Simona; My, Ilaria; Freimark, Dov; Murgia, Marta; Santamaria, Gianluca; Gherghiceanu, Mihaela; Arad, Michael; Moretti, Alessandra; Binah, Ofer
Abstract:
AIMS: Dilated cardiomyopathy (DCM), a myocardial disorder that can result in progressive heart failure and arrhythmias, is defined by ventricular chamber enlargement and dilatation, and systolic dysfunction. Despite extensive research, the pathological mechanisms of DCM are unclear mainly due to numerous mutations in different gene families resulting in the same outcome-decreased ventricular function. Titin (TTN)-a giant protein, expressed in cardiac and skeletal muscles, is an important part of...     »
Journal title abbreviation:
PLoS ONE
Year:
2018
Journal volume:
13
Journal issue:
10
Pages contribution:
e0205719
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0205719
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30332462
Print-ISSN:
1932-6203
TUM Institution:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin; I. Medizinische Klinik und Poliklinik (Kardiologie)
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