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Title:

Subtype-specific Optical Action Potential Recordings in Human Induced Pluripotent Stem Cell-derived Ventricular Cardiomyocytes.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
Author(s):
Goedel, Alexander; Zawada, Dorota M; Zhang, Fangfang; Chen, Zhifen; Moretti, Alessandra; Sinnecker, Daniel
Abstract:
Cardiomyocytes generated from human induced pluripotent stem cells (iPSC-CMs) are an emerging tool in cardiovascular research. Rather than being a homogenous population of cells, the iPSC-CMs generated by current differentiation protocols represent a mixture of cells with ventricular-, atrial-, and nodal-like phenotypes, which complicates phenotypic analyses. Here, a method to optically record action potentials specifically from ventricular-like iPSC-CMs is presented. This is achieved by lentivi...     »
Journal title abbreviation:
J Vis Exp
Year:
2018
Journal issue:
139
Language:
eng
Fulltext / DOI:
doi:10.3791/58134
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30320759
Print-ISSN:
1940-087X
TUM Institution:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin; I. Medizinische Klinik und Poliklinik (Kardiologie)
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