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Titel:

Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy.

Dokumenttyp:
Journal Article; Article
Autor(en):
Schick, Revital; Mekies, Lucy N; Shemer, Yuval; Eisen, Binyamin; Hallas, Tova; Ben Jehuda, Ronen; Ben-Ari, Meital; Szantai, Agnes; Willi, Lubna; Shulman, Rita; Gramlich, Michael; Pane, Luna Simona; My, Ilaria; Freimark, Dov; Murgia, Marta; Santamaria, Gianluca; Gherghiceanu, Mihaela; Arad, Michael; Moretti, Alessandra; Binah, Ofer
Abstract:
AIMS: Dilated cardiomyopathy (DCM), a myocardial disorder that can result in progressive heart failure and arrhythmias, is defined by ventricular chamber enlargement and dilatation, and systolic dysfunction. Despite extensive research, the pathological mechanisms of DCM are unclear mainly due to numerous mutations in different gene families resulting in the same outcome-decreased ventricular function. Titin (TTN)-a giant protein, expressed in cardiac and skeletal muscles, is an important part of...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2018
Band / Volume:
13
Heft / Issue:
10
Seitenangaben Beitrag:
e0205719
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0205719
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30332462
Print-ISSN:
1932-6203
TUM Einrichtung:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin; I. Medizinische Klinik und Poliklinik (Kardiologie)
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