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Title:

Single Molecule Force Spectroscopy Reveals Two-Domain Binding Mode of Pilus-1 Tip Protein RrgA of Streptococcus pneumoniae to Fibronectin.

Document type:
Journal Article
Author(s):
Becke, Tanja D; Ness, Stefan; Gürster, Raimund; Schilling, Arndt F; di Guilmi, Anne-Marie; Sudhop, Stefanie; Hilleringmann, Markus; Clausen-Schaumann, Hauke
Abstract:
For host cell adhesion and invasion, surface piliation procures benefits for bacteria. A detailed investigation of how pili adhere to host cells is therefore a key aspect in understanding their role during infection. Streptococcus pneumoniae TIGR 4, a clinical relevant serotype 4 strain, is capable of expressing pilus-1 with terminal RrgA, an adhesin interacting with host extracellular matrix (ECM) proteins. We used single molecule force spectroscopy to investigate the binding of full-length Rrg...     »
Journal title abbreviation:
ACS Nano
Year:
2018
Journal volume:
12
Journal issue:
1
Pages contribution:
549-558
Language:
eng
Fulltext / DOI:
doi:10.1021/acsnano.7b07247
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29298375
Print-ISSN:
1936-0851
TUM Institution:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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