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Title:

Differentiating supraclavicular from gluteal adipose tissue based on simultaneous PDFF and T2 * mapping using a 20-echo gradient-echo acquisition.

Document type:
Journal Article
Author(s):
Franz, Daniela; Diefenbach, Maximilian N; Treibel, Franziska; Weidlich, Dominik; Syväri, Jan; Ruschke, Stefan; Wu, Mingming; Holzapfel, Christina; Drabsch, Theresa; Baum, Thomas; Eggers, Holger; Rummeny, Ernst J; Hauner, Hans; Karampinos, Dimitrios C
Abstract:
BACKGROUND: Adipose tissue (AT) can be classified into white and brown/beige subtypes. Chemical shift encoding-based water-fat MRI-techniques allowing simultaneous mapping of proton density fat fraction (PDFF) and T2 * result in a lower PDFF and a shorter T2 * in brown compared with white AT. However, AT T2 * values vary widely in the literature and are primarily based on 6-echo data. Increasing the number of echoes in a multiecho gradient-echo acquisition is expected to increase the precision of AT T2 * mapping. PURPOSE: 1) To mitigate issues of current T2 *-measurement techniques through experimental design, and 2) to investigate gluteal and supraclavicular AT T2 * and PDFF and their relationship using a 20-echo gradient-echo acquisition. STUDY TYPE: Prospective. SUBJECTS: Twenty-one healthy subjects. FIELD STRENGTH/SEQUENCE ASSESSMENT: First, a ground truth signal evolution was simulated from a single-T2 * water-fat model. Second, a time-interleaved 20-echo gradient-echo sequence with monopolar gradients of neck and abdomen/pelvis at 3 T was performed in vivo to determine supraclavicular and gluteal PDFF and T2 *. Complex-based water-fat separation was performed for the first 6 echoes and the full 20 echoes. AT depots were segmented. STATISTICAL TESTS: Mann-Whitney test, Wilcoxon signed-rank test and simple linear regression analysis. RESULTS: Both PDFF and T2 * differed significantly between supraclavicular and gluteal AT with 6 and 20 echoes (PDFF: P < 0.0001 each, T2 *: P = 0.03 / P < 0.0001 for 6/20 echoes). 6-echo T2 * demonstrated higher standard deviations and broader ranges than 20-echo T2 *. Regression analyses revealed a strong relationship between PDFF and T2 * values per AT compartment (R2 = 0.63 supraclavicular, R2 = 0.86 gluteal, P < 0.0001 each). DATA CONCLUSION: The present findings suggest that an increase in the number of sampled echoes beyond 6 does not affect AT PDFF quantification, whereas AT T2 * is considerably affected. Thus, a 20-echo gradient-echo acquisition enables a multiparametric analysis of both AT PDFF and T2 * and may therefore improve MR-based differentiation between white and brown fat. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019; 50:424-434.
Journal title abbreviation:
J Magn Reson Imaging
Year:
2019
Journal volume:
50
Journal issue:
2
Pages contribution:
424-434
Language:
eng
Fulltext / DOI:
doi:10.1002/jmri.26661
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30684282
Print-ISSN:
1053-1807
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin; Fachgebiet Neuroradiologie (Prof. Zimmer)
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