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Title:

Common variants in glyoxalase I do not increase chronic pancreatitis risk.

Document type:
Journal Article
Author(s):
Kaune, Tom; Hollenbach, Marcus; Keil, Bettina; Chen, Jian-Min; Masson, Emmanuelle; Becker, Carla; Damm, Marko; Ruffert, Claudia; Grützmann, Robert; Hoffmeister, Albrecht; Te Morsche, Rene H M; Cavestro, Giulia Martina; Zuppardo, Raffaella Alessia; Saftoiu, Adrian; Malecka-Panas, Ewa; Głuszek, Stanislaw; Bugert, Peter; Lerch, Markus M; Weiss, Frank Ulrich; Zou, Wen-Bin; Liao, Zhuan; Hegyi, Peter; Drenth, Joost Ph; Riedel, Jan; Férec, Claude; Scholz, Markus; Kirsten, Holger; Tóth, Andrea; Ewers, M...     »
Abstract:
INTRODUCTION: Chronic pancreatitis (CP) may be caused by oxidative stress. An important source of reactive oxygen species (ROS) is the methylglyoxal-derived formation of advanced glycation endproducts (AGE). Methylglyoxal is detoxified by Glyoxalase I (GLO1). A reduction in GLO1 activity results in increased ROS. Single nucleotide polymorphisms (SNPs) of GLO1 have been linked to various inflammatory diseases. Here, we analyzed whether common GLO1 variants are associated with alcoholic (ACP) and...     »
Journal title abbreviation:
PLoS ONE
Year:
2019
Journal volume:
14
Journal issue:
10
Fulltext / DOI:
doi:10.1371/journal.pone.0222927
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31661534
Print-ISSN:
1932-6203
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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