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Titel:

Common variants in glyoxalase I do not increase chronic pancreatitis risk.

Dokumenttyp:
Journal Article
Autor(en):
Kaune, Tom; Hollenbach, Marcus; Keil, Bettina; Chen, Jian-Min; Masson, Emmanuelle; Becker, Carla; Damm, Marko; Ruffert, Claudia; Grützmann, Robert; Hoffmeister, Albrecht; Te Morsche, Rene H M; Cavestro, Giulia Martina; Zuppardo, Raffaella Alessia; Saftoiu, Adrian; Malecka-Panas, Ewa; Głuszek, Stanislaw; Bugert, Peter; Lerch, Markus M; Weiss, Frank Ulrich; Zou, Wen-Bin; Liao, Zhuan; Hegyi, Peter; Drenth, Joost Ph; Riedel, Jan; Férec, Claude; Scholz, Markus; Kirsten, Holger; Tóth, Andrea; Ewers, M...     »
Abstract:
INTRODUCTION: Chronic pancreatitis (CP) may be caused by oxidative stress. An important source of reactive oxygen species (ROS) is the methylglyoxal-derived formation of advanced glycation endproducts (AGE). Methylglyoxal is detoxified by Glyoxalase I (GLO1). A reduction in GLO1 activity results in increased ROS. Single nucleotide polymorphisms (SNPs) of GLO1 have been linked to various inflammatory diseases. Here, we analyzed whether common GLO1 variants are associated with alcoholic (ACP) and...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2019
Band / Volume:
14
Heft / Issue:
10
Volltext / DOI:
doi:10.1371/journal.pone.0222927
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31661534
Print-ISSN:
1932-6203
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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